Since the 1960s, increased health spending has caused much concern all over the world. Researches done on this subject while one hand have tried to explain the causes of the increase in health expenditures, on the other hand, investigated which variables could be affected to reduce costs. The aim of this study is to investigate the trends and determinants of health spending by means of panel data method for Level 2 Region in Turkey. As a result of the analysis, while there was statistically significant and positive relationship between health expenditures and population, inflation rate and tax rate; statistically significant yet negative correlation was found between health expenditures, infant mortality rate and literacy rate.